Wood-derived dietary fibers promote beneficial human gut microbiota (2024)

La Rosa, Sabina Leanti, Kachrimanidou, Vasiliki, Buffetto, Fanny, Pope, Phillip B., Pudlo, Nicholas A., Martens, Eric C., Rastall, Robert A., Gibson, Glenn R., & Westereng, Bjørge(2019)Wood-derived dietary fibers promote beneficial human gut microbiota.mSphere, 4(1), Article number: e00554-18.

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Description

<p>Woody biomass is a sustainable and virtually unlimited source of hemicellulosic polysaccharides. The predominant hemicelluloses in softwood and hardwood are galactoglucomannan (GGM) and arabinoglucuronoxylan (AGX), respectively. Based on the structure similarity with common dietary fibers, GGM and AGX may be postulated to have prebiotic properties, conferring a health benefit on the host through specific modulation of the gut microbiota. In this study, we evaluated the prebiotic potential of acetylated GGM (AcGGM) and highly acetylated AGX (AcAGX) obtained from Norwegian lignocellulosic feedstocks in vitro. In pure culture, both substrates selectively promoted the growth of Bifidobacterium, Lactobacillus, and Bacteroides species in a manner consistent with the presence of genetic loci for the utilization of β-manno-oligosaccharides/β-mannans and xylo-oligosaccharides/ xylans. The prebiotic potential of AcGGM and AcAGX was further assessed in a pHcontrolled batch culture fermentation system inoculated with healthy adult human feces. Results were compared with those obtained with a commercial fructooligosaccharide (FOS) mixture. Similarly to FOS, both substrates significantly increased (P < 0.05) the Bifidobacterium population. Other bacterial groups enumerated were unaffected with the exception of an increase in the growth of members of the Bacteroides-Prevotella group, Faecalibacterium prausnitzii, and clostridial cluster IX (P < 0.05). Compared to the other substrates, AcGGM promoted butyrogenic fermentation whereas AcAGX was more propiogenic. Although further in vivo confirmation is necessary, these results demonstrate that both AcGGM and AcAGX from lignocellulosic feedstocks can be used to direct the promotion of beneficial bacteria, thus exhibiting a promising prebiotic ability to improve or restore gut health.</p>

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52 citations in Scopus

51 citations in Web of Science®

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ID Code: 252626
Item Type: Contribution to Journal (Journal Article)
Refereed: Yes
Measurements or Duration: 16 pages
Keywords: carbohydrate-active enzymes, Dietary fibers, Gut microbiota, Hemicellulose, In vitro fecal fermentation, Prebiotics, Short-chain fatty acids
DOI: 10.1128/mSphere.00554-18
ISSN: 2379-5042
Pure ID: 179178903
Funding Information: We thank Carlos Poveda of the University of Reading Department of Food and Nutritional Sciences for excellent technical assistance with flow cytometry. We thank G. Mathiesen, D. B. Diep, and K. Rudi for kindly providing the Lactobacillus and Bifidobacterium strains. This research was financed by the Norwegian Research Council under grant number 244259. Experiments were primarily designed by S.L.L.R., V.K., G.G., E.C.M., and B.W. S.L.L.R. and V.K. conducted the in vitro batch culture fermentation, FISH-FCM, and organic acid analyses. Growth experiments were conducted by S.L.L.R. and N.A.P. F.B. conducted the monosaccharide composition analysis. Production of AcGGM and AcAGX was performed by B.W. S.L.L.R. analyzed the data, performed the comparative genomic analyses, and wrote the manuscript. B.W., V.K., P.B.P., G.G., R.A.R., and E.C.M. discussed and revised the manuscript. The figures were prepared by S.L.L.R. All of us read and approved the final manuscript.
Copyright Owner: 2019 The Authors
Copyright Statement: This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
Deposited On: 15 Oct 2024 05:34
Last Modified: 15 Oct 2024 23:27

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Wood-derived dietary fibers promote beneficial human gut microbiota (2024)

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